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Additional info for Glioblastoma Multiforme - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
To determine a maximum tolerated dose (MTD) for cranial NCT. ) To examine, through serial objective measurements, the clinical response of metastatic melanoma nodules and glioblastoma multiforme following NCT. ) To further the level of understanding of the pharmacokinetics of 1 -boronophenylalanine-fructose (BPA-f) through the measurement of blood and plasma concentrations of 10B and the refinement of the predictive accuracy of a two-compartment pharmacokinetic model developed by this research group.
TNP-470 is under evaluation at the MGH using of fMRI and fCT as surrogate markers of glioma angiogenesis. These techniques can be co-registered over FDG-PET images to provide vascular-metabolic maps of tumor, area- around-tumor and normal brain tissue. These maps will be correlated with in vitro analysis of vascular markers performed by our collaborator Dr. S. Brem. (3) Dr. Hochberg brings to NABTT the pilot study of an industry-sponsored assessment of quality of life of American patients with malignant glioma.
Approaches that can enhance the radiosensitivity of such resistant tumor cells are much needed to reduce mortality in cancer patients. We discovered that berberine, a relatively non-toxic compound isolated from Chinese medicinal herbs, could enhance the radiation response of radioresistant human glioma cells in vitro. In addition, we showed that berberine could trigger an endogenous cell-suicide mechanisms, apoptosis, in GM tumor cells that express mutant p53, a genetic defect endogenous cell-suicide mechanism, apoptosis, in GM tumor cells that express mutant p53, a genetic defect thought to contribute to radioresistance in many cell types.