Download Electrical Diseases of the Heart: Genetics, Mechanisms, by Harry A. Fozzard MD (auth.), Ihor Gussak MD, PhD, FACC, PDF

By Harry A. Fozzard MD (auth.), Ihor Gussak MD, PhD, FACC, Charles Antzelevitch PhD, FACC, FAHA, FHRS, Arthur A. M. Wilde MD, PhD, FESC, FAHA, Paul A. Friedman MD, Michael J. Ackerman MD, PhD, FACC, Win-Kuang Shen MD (eds.)

The previous decade has witnessed an explosion of data and radical adjustments in our realizing of the molecular, ionic, genetic, and pharmacologic foundation of electric illnesses of the guts. electric ailments of the guts are heritable arrhythmogenic scientific entities that could proportion universal scientific and genetic good points, but can be surprisingly diverse of their genesis, diagnosis, and administration. particularly, either congenital and bought electric illnesses of the center are receiving elevated popularity because of vital advances in genetic research.

Electrical ailments of the Heart is a radical medical reference at the present prestige of cardiac electrophysiological disease,emphasizing universal and various medical positive factors. the newest advancements within the box of experimental and medical cardiac electrophysiology, genetics, pharmacology, and interventional remedies of assorted scientific arrhythmogenic entities are featured and mentioned when it comes to contemporary advances in uncomplicated and scientific technological know-how. citizens, fellows, and physicians in cardiology and electrophysiology will achieve precious perception into cardiac electrophysiology and scientific electrocardiology via analyzing this publication, together with specialist evaluation of the genetic and epidemiologic issues, diagnostic and healing modalities of the newly came across medical syndromes, and electrocardiographic phenomena, and their correlation with the latest advances within the easy science.

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Additional info for Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention

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21. Makita N, Bennett PB Jr, George AL Jr. Voltagegated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene. J Biol Chem 1994;269:7571– 7578. 22. Thimmapaya R, Neelands T, Niforatos W, et al. 3 splice variants. Eur J Neurosci 2005; 22:1–9. 23. George AL Jr, Knittle TJ, Tamkun MM. Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: Evidence for a distinct gene family. Proc Natl Acad Sci USA 1992;89:4893–4897.

A. Fozzard Summary This brief historical review, with no less than nine Nobelists cited, shows cardiac electrophysiology to be in the mainstream of biomedical science. Progress has been closely tied to the development of new measurement methods and, recently, to our collaboration with the fields of genetics and molecular biology. Conceptual advances in the basic science will continue to depend on avoiding insularity and on exploitation of ideas and methods from the broad range of biomedical and biophysical science.

J Cardiovasc Electrophysiol 2002;13:406–409. 2. Dhamoon AS, Jalife J. The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis. Heart Rhythm 2005;2:316– 324. 3. Kurachi Y, Ishii M. Cell signal control of the G protein-gated potassium channel and its subcellular localization. J Physiol 2004;554:285–294. 4. Song LS, Guatimosim S, Gomez-Viquez L, et al. Calcium biology of the transverse tubules in heart. Ann NY Acad Sci 2005;1047:99–111. 5. Schram G, Pourrier M, Melnyk P, et al.

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