By Prof. Dr. med. G. Zbinden (auth.), Dr. med. C. Steichele, Prof. Dr. med. U. Abshagen, J. Koch-Weser M. D. (eds.)
Franz Gross died unexpectedly in the course of arrangements for the assembly. He could have taken nice excitement in summarizing during this preface the goals and result of a meeting which so basically bore his imprint as Chairman of the clinical application Committee. His unexpected passing away is deeply regretted through we all: organizers, audio system and contributors. We significantly appreciate him for his unparalleled talents, his impression on technological know-how and his traits as a individual. He supplied the impulse for a good balanced and topical medical software. We consequently commit the complaints of this symposium to his reminiscence. Munich used to be the 5th in a conventional line of overseas conferences of pharmaceutical physicians held at three-year durations, beginning in London in 1972 ('International facets of Drug evaluate and Usage'), and by way of Florence in 1975 (,Rationality of Drug Development'), Brussels in 1978 (,Pharmaceutical drugs - the Future') and Paris in 1981 ('Drug defense -;- development and Controversies'). This fifth assembly mentioned advancements in drug improvement and alertness and tested the impression of regulatory activities.
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Extra info for Drugs between Research and Regulations: Proceedings of the 5th International Meeting of Pharmaceutical Physicians Munich, October 14–17, 1984
International Agency for Research on Cancer. Lyon, p 311425 20. Rinkus SJ, Legator MS (1979) Chemical Characterization of 465 Known or Suspected Carcinogens and Their Correlation with Mutagenic Activity in the Salmonella typhimurium system. Cancer Res 39:3289-3318 2l. Rodricks J, Taylor MR (1983) Application of Risk Assessment to Food Safety Decision Making. Regulat Toxicol PharmacoI3:275-307 22. Salsburg D (1980) The Effects of Lifetime Feeding Studies on Patterns of Senile Lesions in Mice and Rats.
They are hailed by some and condemned by others and nine tenths of the problem is that the one party really has little idea what the other party is talking about. If! were asked to say what the term Guideline conveys to me, as someone whose native language was once English, then I would probably answer that a guideline is something more than a casual suggestion and much less than a binding command. At its best, I think one could consider a guideline to be a well thought out piece of advice on the best way to undertake a job, taking into account current knowledge.
In arthritic conditions which fluctuate, it is not surprising that there is great difficulty in showing clear differences between placebo and active substances and that it is impossible to show differences between two active treatments. b) Clinical trials in hypertension A second design and doubt which serves as an example is the study of hypertension and its outcome. Again, there is no doubt from the Framingham Study that high blood pressure influences the frequency of stroke and possibly myocardial infarct, and certainly other factors such as smoking have a clear effect.