By Olga Genilloud
Content material: advent; half one: Semisynthesis/ synthesis de novo of NPs: Semisynthesis process of Ecteinascidin 743 (ET-743, Yondelis(R)); Chondramides and Chivosazoles - metabolites which intrude with the actin cytoskeleton; classification III lantibiotics - an rising relatives of thioether containing peptidesMutant brands; growth in improving the neurotrophic results of traditional FKBP ligands; half : Engineering NP artificial pathways and genome mining: biosynthesis of indolocarbazole alkaloids and new release of novel derivatives through combinatorial biosynthesis; new lantibiotics from typical and engineered lines; mining microbial genomes for metabolic items of cryptic pathways; mining cyanobacterial genomes for drug-like and bioactive average items; pigenetic ways to traditional product synthesis in fungi; half 3: New methodologies and screening applied sciences for the exploitation of microbial assets: novel techniques for exploiting microbial assets at Fundacion MEDINA; discovery and improvement of Platensimycin and Platencin; coupling chemical genomics and typical items: the invention of parnafungins and novel antifungal leads; half 4: Novel microbial common items and derivatives: Retapamulin-a first-in-class pleuromutilin antibiotic; average items: new brokers opposed to MDR tuberculosis; the contribution of marine chemistry within the box of antimalarial study; epothilones as lead buildings for brand spanking new anticancer medicines; destiny demanding situations
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