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By Edward C. Olson and Ralph E. Christoffersen (Eds.)

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In principle, extrathermodynamic relationships that deviate from the simple Hammett equation (equation 8) can be treated by equation 14. , 0*1 set and 0*2 set) i n a way that w i l l indeed reflect their relation to independent properties. An example of such a procedure i s the separation of polar and steric effects (10). The need for such a separation arose when a nearly complete lack of correlation was observed between substituent effects represented by the Hammet a constants and the rates for a l kaline hydrolysis of aliphatic systems (12).

Polar and steric) are associated with these properties (see below). In principle, extrathermodynamic relationships that deviate from the simple Hammett equation (equation 8) can be treated by equation 14. , 0*1 set and 0*2 set) i n a way that w i l l indeed reflect their relation to independent properties. An example of such a procedure i s the separation of polar and steric effects (10). The need for such a separation arose when a nearly complete lack of correlation was observed between substituent effects represented by the Hammet a constants and the rates for a l kaline hydrolysis of aliphatic systems (12).

Polar substituent constants were thus defined as the difference between the rate constants of base and acid catalyzed hydrolysis of esters. 48 4T (log*B X log<£->) o A k - K log^B) (16) X a where B and A refer to base and acid catalyzed hydrolysis, k represents rate constants of hydrolysis of substituted acetates, and k the rate constants of the unsubstituted acetate ester which serves as a reference. 48 was a r b i t r a r i l y introduced so that o* and a have the same range of numerical values.

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