Download Cardiac regeneration and repair: Pathology and therapies by Ren-Ke Li, Richard D. Weisel PDF

By Ren-Ke Li, Richard D. Weisel

Cardiac Regeneration and service, quantity One reports the pathology of cardiac harm and the most recent advances in phone therapy.

Chapters partially one discover the pathogenesis of congestive center failure, the mechanisms chargeable for adversarial cardiac matrix home improvement, and power interventions to revive ventricular functionality. half highlights new ways to mobile treatment for cardiac regeneration, and comprises chapters masking alternative ways of mobile supply, tracking telephone engraftment, and the feasibility of utilizing allogeneic stem cells to revive cardiac functionality. Chapters partially 3 circulation directly to spotlight novel stem cells for cardiac fix, together with human embryonic stem cells and human pluripotent stem cells, and aspect their present prestige and destiny power for cardiac treatment. ultimately, half 4 explores gene treatment, and comprises ultrasound-targeted or direct gene supply in addition to cell-based gene treatment for cardiac regeneration.

Cardiac Regeneration and service, quantity One is complemented by way of a moment quantity masking biomaterials and tissue engineering. jointly, the 2 volumes of Cardiac Regeneration and Repair supply a complete source for clinicians, scientists, or academicians interested by cardiac regeneration, together with these drawn to telephone treatment, tissue engineering, or biomaterials.

  • Explores the pathogenesis of congestive middle failure, the mechanisms chargeable for antagonistic cardiac matrix home improvement, and capability interventions to revive ventricular function
  • Highlights new techniques to mobile remedy for cardiac regeneration and contains chapters protecting alternative ways of mobilephone supply, tracking cellphone engraftment, and the feasibility of utilizing allogeneic stem cells to revive cardiac function
  • Explores gene treatment and comprises ultrasound-targeted or direct gene supply in addition to cell-based gene treatment for cardiac regeneration

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1995) Regulation of collagen degradation in the rat myocardium after infarction. J Mol Cell Cardiol 27: 1281–1292. 52. Kim HE, Dalal SS, Young E, et al. (2000) Disruption of the myocardial extracellular matrix leads to cardiac dysfunction. J Clin Invest 106: 857–866. 53. Spinale FG, Coker ML, Bond BR and Zellner JL. (2000) Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target. Cardiovasc Res 46: 225–238. 54. Foronjy RF, Sun J, Lemaitre V and D’Armiento JM.

In theory, global function is the sum of the function in all regions of the heart. If a region of the heart is dysfunctional, it will result in a decrease in global function. However, as the heart does not always operate at 100% capacity, the effects of decreased regional function may not be seen until the heart is placed under stress, such as physical exercise. In addition, many of the measures of global function are not sensitive enough to pick up either small changes in large regions or large changes in small regions.

2006) Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 69: 562–573. 44. Nagase H and Woessner Jr JF. (1999) Matrix metalloproteinases. J Biol Chem 274: 5578–5582. 45. Cao J, Drews M, Lee HM, et al. (1998) The propeptide domain of membrane type 1 matrix metalloproteinase is required for binding of tissue inhibitor of metalloaproteinases and for activation of pro-gelatinase a. J Biol Chem 273: 34745–34752. 20 Cardiac regeneration and repair 46. Jugdutt BI. (1985) Delayed effects of early infarct-limiting therapies on healing after myocardial infarction.

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