By Martin Röcken, Tilo Biedermann (auth.), Michael Hertl MD (eds.)
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Extra info for Autoimmune Diseases of the Skin: Pathogenesis, Diagnosis, Management
Adv Immunol 71: 229-265 Strober W, Ehrhardt RO (1993) Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice. Cell 75: 203-205 Tessari G, Barba A, Schena D (1996) Lichen ruber planus following the administration of human anti-hepatitis B virus immunoglobulins [letter]. Acta Derm Venereol 76: 154 Vollmer S, Menssen A, Trommler P, Schendel D, Prinz JC (1994) T lymphocytes derived from skin lesions of patients with psoriasis vulgaris express a novel cytokine pattern that is distinct from that of T helper type 1 and T helper type 2 cells.
Cell 65: 293-304 Schuler G, Steinman RM (1997) Dendritic cells as adjuvants for immune-mediated resistance to tumors. J Exp Med 186: 1183-1187 Schuler G, Thurner B, Romani N (1997) Dendritic cells: from ignored cells to major players in T-cell-mediated immunity. Int Arch Allergy Immunol 112: 317-322 Schwartz RH (1998) Immunological tolerance. In Fundamental Immunology, 4th Edition, Paul WE (ed) Lippincott-Raven, Philadelphia, New York, 701-740 Sinha AA, Lopez MT, McDevitt HO (1990) Autoimmune diseases: the failure of self tolerance.
A stringent design tries to minimize bias and therefore errors in the interpretation of the results of a study. Study design is determined by the frequency of a disease. For rare diseases- such as cutaneous autoimmune diseases -the cross-sectional or case-control design will lead to the fastest results. If several studies with inconclusive or controversial results are available, different studies can be polled together in a meta-analysis which was shown for breast implants and CTD where cross-sectional studies, cohort studies and case control studies were analyzed together (Perkins et al.