By Rakesh N. Veedu
Aptamers, usually termed as ‘chemical antibodies,’ are an rising classification of artificial ligands for effective target-specific molecular popularity. the target of this booklet is to focus on fresh advances and capability of aptamers in a number of disorder stipulations. . This e-book makes a speciality of the functions of aptamers in detailed nanotherapy, detection, and in molecular imaging in a number of affliction stipulations comparable to melanoma, neurological ailments and infectious diseases.
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Extra info for Aptamers: Tools for Nanotherapy and Molecular Imaging
And Heyduk, T. (2009). Bivalent ligands with long nanometerscale ﬂexible linkers, Biochemistry, 48, pp. 264–275. 56. Ahmad, K. , and Soh, H. T. (2012). , 40, pp. 11777–11783. 57. , Chaudhuri, R. , and Cossins, A. (2014). Single-step selection of bivalent aptamers validated by comparison with SELEX using high-throughput sequencing, PLoS One, 9, p. e100572. 58. , Oh, S. , Radeke, M. , Coﬀey, P. , Thomson, J. , and Soh, H. T. (2015). Array-based discovery of aptamer pairs, Anal. , 87, pp. 821–828.
Diﬀerent pH dependence on hydrogen and electrostatic bond formation) and conformational ﬂexibility , which translates to a plethora of conﬁgurations capable of binding to various molecular surfaces, thus improving the chances of ﬁnding an ideal interactor. Similar to antibodies in binding aﬃnity with nanomolar to picomolar binding constants, PAs are less immunogenic and smaller (10–50 kDa) and can be used in a variety of environmental conditions. But the greatest advantage is the speed of generating, selecting, and evolving PAs .
E65497. 91. , and Ikebukuro, K. (2015). Improvement of the VEGF binding ability of DNA aptamers through in silico maturation and multimerization strategy, J. , 212, pp. 99–105. 01-Veedu-Rakesh-c01 April 7, 2016 10:3 PSP Book - 9in x 6in Chapter 2 Thioredoxin-Based Peptide Aptamers: Development and Applications David S. 1 Introduction The ability to control the dynamic network of complex cellular signaling and macromolecular interactions that govern living processes is the Holy Grail of biomedicine .